Marble Burying Test Autism

The marble burying test is commonly used to detect repetitive digging behavior servadio et al 2015.

Marble burying test autism. The number of marbles that were buried by the mouse was measured. For the communication domain neonatal ultrasonic vocalization and olfactory habituation test toward social and non social odor are described. Burrows escape tunnels and in standard cage bedding and the nestlet shred test capitalizes on the fact that mice are nesting animals by nature that build nests for protection of themselves and their offspring against environmental conditions e g. In the current study significant differences in marble burying behavior were observed between pm 2 5 exposed and control rats figure 1b and supplementary figure 3 f 3 35 37 56 p 001.

The marble burying test occurred 8 days following the grooming test to ensure there were no potential residual effects from the initial drug treatment birdsall et al 1978. When put in a cage with marbles mice with ocd like symptoms tend to engage in a high degree of repetitive behaviors including digging while mice with a high degree of anxiety tend to engage in a high degree of digging in novel contexts potentially as a means to attempt. Marble burying is an animal model used in scientific research to depict anxiety or obsessive compulsive disorder ocd behavior. In this unit behavioral tests are described that are relevant to the domains affected in asd.

For the repetitive domain the t maze spontaneous alternation test and marble burying test are described. The marble burying test takes advantage of the proclivity of mice to dig in natural settings e g. Each mouse was placed for 45 min into a clean rat cage with 4 cm deep bedding and 12 glass marbles placed on the surface. Behavior obsessive compulsive disorder autism spectrum disorder mouse marble burying this is a preview of subscription content log in to check access.

Springer nature is developing a new tool to find and evaluate protocols. Santini et al 2013. It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding. Choi et al 2016.

The marble burying test protocol described below is modified from deacon 2006 and angoa perez kane. Marble burying test and self grooming behavior. The marble burying test is a useful model of both obsessive compulsive like ocd behavior and or anxiety like behavior. The marble burying test in animal models of asd such as the btbr t tf j mouse eif4e transgenic mice 4e tg as well as in the maternal immune activation mouse model amodeo et al 2012.

Table 3 marble burying behavior in a two compartment box no. Zimeldine 10 0 mg kg reduced marble burying without affecting locomotor activity.